Warning: your taste buds are about to revolt. In the quiet corners of South Carolina, far from the tourist crowds, small-town kitchens are cooking up mac and cheese so creamy, so rich, and so decadently cheesy, it stops you mid-bite. This isn’t your average boxed pasta — this is indulgence with a southern twist. Whether you’re driving the backroads or taking a weekend detour, these restaurants prove that great comfort food doesn’t need a big city address.
They’re the kind of stops that make your stomach cheer and your heart happy. Prepare for cheese. Prepare for joy. Prepare to get lost in flavor.
Crave Kitchen & Cocktails
Crave Kitchen & Cocktails in Mount Pleasant offers an indulgent take on mac and cheese. Their “Famous Mac & Cheese” blends cheddar, Parmesan, mozzarella, and a secret ingredient for a velvety texture.
It can be elevated with scallops, short-rib, or truffled mushrooms, making it a favorite among mac lovers.
Enjoy it during lunch or dinner in a setting that combines modern elegance with Southern charm.
With moderate pricing, this dish is a must-try for those who appreciate creamy richness with a gourmet twist.
Cherrywood BBQ & Ale House
At Cherrywood BBQ & Ale House on Kiawah Island, the four-cheese mac has achieved legendary status. Its creamy blend complements their smoked meats perfectly.
Though part of a resort, this gem is accessible to non-guests, making it an exclusive yet welcoming dining spot. The mac has won both People’s and Critics’ Choice awards, marking it as a standout choice.
Reservations or gate access may be needed, but the flavorful experience awaits those who venture here.
Big Mike’s Soul Food
Big Mike’s Soul Food in Myrtle Beach is where mac and cheese meets Southern hospitality. Their baked version, often served in generous portions, pairs brilliantly with fried fish or collard greens.
The soul-food atmosphere is down-to-earth, offering a no-frills experience that emphasizes flavor and comfort. Prices are wallet-friendly, appealing to both locals and travelers.
For those seeking traditional Southern fare, Big Mike’s provides a heartwarming meal filled with homestyle goodness.
The Dixie Pig
The Dixie Pig in Rock Hill offers a twist on traditional mac and cheese with a savory crust that adds a delightful texture. This barbecue-style restaurant is famed for its comfort food vibe.
Patrons love the contrast between the creamy macaroni and crispy top, making it a favorite for texture enthusiasts. The casual setting makes it a welcoming stop for hungry travelers.
With its down-home cooking, it’s a worthy detour for those exploring the Piedmont region.
Julia Belle’s
Julia Belle’s in Florence serves a mac and cheese that captures the essence of Southern cuisine. Its creamy base is enhanced by chicken broth, garlic, and mustard, adding depth to the cheesiness.
This dish stands alone, showcasing how mac and cheese can be a satisfying meal on its own. The homey restaurant environment adds to the delightful dining experience.
A perfect stop for those in search of a comforting dish that goes beyond the basics.
Favor Home Cooking
Favor Home Cooking in Anderson offers mac and cheese that feels like a warm hug from home. Its simple, creamy preparation is reminiscent of a homemade casserole.
This soul-food-style restaurant provides hearty portions that satisfy cravings for traditional Southern comfort food. The cozy setting invites diners to relax and enjoy a meal that feels personal.
For those seeking authentic Lowcountry charm, Favor Home Cooking delivers a delightful experience off the beaten path.
Smoky Dreams BBQ
Smoky Dreams BBQ in Greenville elevates mac and cheese to new heights. Known for its deeply cheesy consistency, it complements their slow-smoked meats beautifully.
The growing food scene in Greenville makes this spot a must-visit for comfort food enthusiasts. Fans rave about the rich flavors and hearty portions.
Perfect for those wanting classic Southern BBQ with standout sides, Smoky Dreams is a flavorful stop on any culinary journey.
One Hot Mama’s
One Hot Mama’s in Hilton Head Island serves up bold, flavorful mac and cheese topped with a crispy breadcrumb crust. This adds a satisfying crunch to the creamy pasta beneath.
Situated near the coast, it offers a hearty, comforting meal ideal after a day on the beach. The vibrant atmosphere matches the dish’s lively flavors.
For visitors seeking a dish with a bit of flair and texture, One Hot Mama’s delivers a memorable dining experience.
Midwood Smokehouse
Midwood Smokehouse in Columbia is where mac and cheese meets smoky BBQ delight. Its full-bodied cheesiness is topped with a nicely browned crust, perfect for comfort food lovers.
Located in the vibrant capital, it offers a classic Southern BBQ experience that’s hard to beat. The restaurant’s lively atmosphere enhances the enjoyment of the rich, soulful dish.
A great choice for those looking to indulge in traditional flavors with modern flair.
Swig & Swine
Swig & Swine in Charleston crafts mac and cheese baked to bubbly perfection, often infused with peppery notes. It serves as a comforting side to their renowned BBQ meats.
The laid-back vibe and outdoor seating make it a popular choice for both locals and visitors. The friendly Lowcountry hospitality adds to the charm.
A casual yet satisfying meal awaits those exploring Charleston’s rich culinary scene, making it a worthwhile stop.